Give Injections the Boot

Finally! A new age in discovery has created a formula so effective at diminishing wrinkles and creating a more youthful 'you', its one of the first cosmetic products to give you a legitimate alternative to Botulinum Toxin Type A injections.

Protox has been proven to reduce the depth of the wrinkles around the eyes caused by the contraction of the muscles of facial expression.

Protox prevents aging of the skin induced by repeated facial movements mediated by excessive catecholamines release.

Protox has been trialled by users to establish whether it can reducing the number required procedures.

Protox is applied as a gel, that moisturises and hydrates.

Botulinum Toxin is a nerve agent that blocks muscle contraction. Protox is the original Professional Toxin (hence ProTOX) subsitute gel, that is an injection-free alternative and works to relax muscles in a similar way to Botulinum Toxin injections. Protox contains, amongst other advanced ingredients, Argireline Hexapeptide-3 as supplied under license. Formulated according to the clinical trial data and at double dose. Both formulae are encapsulated in a Liposome delivery system.

Visible Results
Using a device simlilar to those found in opticians to keep your head still and in one place, we photographed several test subjects with moderate wrinkles both prior to using Protox and after 30 days of applying Protox gel twice daily in 3 affected areas: a) the forehead furrows; b) the eye 'crow feet' and c) the smile creases.

Three markers were used to allow easy comparison between images. Notice how wrinkles denoted by the Arrows Blue and Red have become much less visible. Arrow Green has also shown pronounced visible benefit. Constant muscle movements in this area of the skin lead to frequent skin creasing which ends in wrinkles and fine lines. Protox can halt this.

Better than the rest
You can find more detail on Catecholamine release and how this affects muscle tone and wrinkle definition in the "Science Section". Simply put, the more Catecholamine that is released by facial muscle nerves in response to Noradrenaline and/or Adrenaline stimulus, the more wrinkles that will appear and the deeper they will be.

What is the difference between Protox-10 and Protox-20?
Protox-10 and 20 both contains all the same ingredients even including Hyaluronic Acid to help prevent & repair and cross-linking. Both use our unique Liposome Delivery System to increase transcutaneous absorption. The sole difference between the two formulae is that Protox-10 contains 10% Argireline and Protox-20 contains 20% Argireline making the latter twice as powerful.

THERE IS NO STRONGER TOPICAL BOTOX ALTERNATIVE THAN PROTOX-20

We recommend that people under 40 years old with light wrinkles should use Protox-10

We recommend that more mature skin should use Protox-20

Of course, a number of other combinations or patterns have been observed by prescribing skin care professionals. Sometimes, a patient will commence treatment with Protox-20 and then after 2 months, switch to Protox-10. Alternatively, some use Protox-20 at night while sleeping and Protox-10 during the day.

Our resident skin care professional will be glad to advise you by email or telephone. Of course you can get the same advise from your local skin care specialist and/or Protox stockist.

How Protox Works

Before you can understand how Protox works, you need to be familiar with how muscle contractions are stimulated. Remember, it is the attenuation or muting of muscle contraction in the facial muscle groups which allows wrinkles to 'flatten out' and become much less visible. The following is for educational purposes only.

When a nerve fires an 'action potential' which is a wave of cell wall depolarization, travels down the nerve fibre until it reaches the synaptic cleft (see left) which is the gap between the nerve and muscle tissue. The two tissues are not physically connected otherwise all 'flashes' of nerve activity would cause muscle contraction irrespective of the intensity or duration of nerve impulse.

An action potential must reach a certain level before it causes the 'synaptic vesicles' to fuse with the neurone cell wall (called exocytosis). This is rather like a soap bubble bursting and releasing it's contents into the surface that bumps into. In this case however, the contents of the vesicle is a neuro-transmitter called Acetylcholine (Ach). The ACh is therefore released into the synapic cleft space where the majority is taken back up by the nerve or broken down by an enzyme present in the synaptic cleft called Acetylcholisterase. Again if only a small amount of ACh reaches the muscle receptors, a contraction will not take place - so the small amount not re-absorbed or not broken down and reaching the muscle receptors will not cause a muscle contraction.

As the nerve action potential gets more and more intense, more ACh is released eventually leading to sufficient ACh landing on the muscle receptors, which then react by changing shape and letting in sodium ions. The inflood of positively charged Sodium ions sets up a new wave of depolarisation in the muscle fibre causing a contraction.

The diagram to the left shows the mechanism of action of Protox-like peptides. Note how two vesicles are releasing Ach into the synapse above but now with Protox added, only one vesicle fuses with the nerve fibre cell wall, thereby reducing the amount of Ach released or another way of looking at it - increasing the amount of stimulation required before muscle contractions occurs.

Advanced Explanation:
Protox contains a small hexapeptide that is designed to partially interfere with the SNARE (which is a ternary complex formed by the proteins VAMP, Syntaxin and SNAP-25) This complex intervenes in the process of docking, fusing and exocytosis of these neuro-transmitter vesicles.

Protox is a mimic of the N-Terminal end of SNAP-25 which can therefore compete for a position in the SNARE complex, thereby modulating it's formation. If the complex is slightly destabilised, the vesicle is not able to release as much neuro-transmitter, thereby muting muscle contraction and helping to prevent the formation & visibility of wrinkles.

• Facial rejuvenation treatments to:
  • smooth frown lines and forehead lines
  • reduce crows feet and squint lines
  • uplift down turned corners of the mouth
  • eliminate "bunny" lines on either side of the nose
  • treat puckering of the chin
• Facial enhancement treatments to:
  • create an enhanced natural lip border
  • produce a lip pout
  • enhance cheek bones
  • create a more pronounced chin
• Facial corrective treatments to:
  • reduce lines around the mouth
  • reduce lines running from base of the nose to corner of mouth
  • reduce scars
  • reduce frown and forehead lines
  • reducte facial wrinkles
• Skin care & beauty treatments:
  • anti-ageing skin care products
  • semi-permanent make up